Head Coach Ceri Jones also recalls a number of his Wales stars, following their Grand Slam exploits, as Dragons make a total of eight changes for the clash in Swansea.
Number Eight Ross Moriarty and flanker Aaron Wainwright return in the back row alongside Taine Basham.
Prop Leon Brown makes a start and packs down alongside captain Richard Hibbard, who is declared fit after missing the home defeat to Ulster Rugby.
Fly half Jason Tovey starts the game just three points shy of hitting 1,000 for the region and will team up at half back with Rhodri Williams.
Centre Tyler Morgan is also recalled alongside wing Jared Rosser.
Jones said: “We’re all looking forward to the derby and know the challenge we will face down at Ospreys.
“We will need to replicate the physicality we produced when we beat them in December and ensure our accuracy is good then we feel we can get a positive result.
“Having some of our Wales contingent certainly back adds to us and we look forward to seeing them build on recent performances back in a Dragons jersey.”
Dragons (v Ospreys): Jordan Williams, Jared Rosser, Tyler Morgan, Jarryd Sage, Hallam Amos, Jason Tovey, Rhodri Williams; Brok Harris, Richard Hibbard (c), Leon Brown, Max Williams, Matthew Screech, Aaron Wainwright, Taine Basham, Ross Moriarty
Replacements: Rhys Lawrence, Josh Reynolds, Lloyd Fairbrother, Joe Davies, Lennon Greggains, Tavis Knoyle, Josh Lewis, Dafydd Howells
The Guinness PRO14 Final is one of the most entertaining games in the rugby calendar and takes place in Glasgow’s Celtic Park on May 25. Tickets start at just £25 for adults, £1 for kids. Visit www.pro14rugby.org/finaltickets