As Edinburgh look to secure their fifth consecutive home victory in all competitions, three players are rotated into the backline. James Johnstone and Juan Pablo Socino are named in the midfield, while winger Darcy Graham makes his first start since featuring against Leinster in February.
Cockerill makes just one change to the pack as Rory Sutherland makes his first start of the season at loosehead prop.
On his selection, Cockerill, said: “We’ve named a strong, combative side who’ll be looking to make amends following last weekend’s disappointing performance against Benetton.
“Whilst we were happy with the result and certain aspects of our play, the squad know that there is plenty to improve on if we’re going to challenge in the league.
“Cheetahs are a physical, abrasive outfit with quick backs out wide that’ll punish you throughout the 80 minutes. However, we’ve got plenty of belief, especially at home, and I’ve got every confidence that this group of players can bounce back tomorrow night.”
After crossing the whitewash against Benetton a week ago, Blair Kinghorn is named at fullback, with Duhan van der Merwe – a try-scorer in his last four appearances at BT Murrayfield – and Graham selected on the flanks.
Johnstone and summer recruit Socino get the nod in midfield, while Henry Pyrgos and Kiwi stand-off Simon Hickey continue at half-back.
Up-front, hooker Stuart McInally skippers the side and packs down alongside WP Nel and Sutherland.
Experienced locks Grant Gilchrist and Ben Toolis are named in the boiler room, while Magnus Bradbury, Hamish Watson and Fijian international Bill Mata complete the back-row.
Edinburgh team to face Cheetahs at BT Murrayfield in the Guinness PRO14 on Friday 5 October, kick-off 7.35pm – live on Free Sports.
15. Blair Kinghorn (68)
14. Darcy Graham (6)
13. James Johnstone (22)
12. Juan Pablo Socino (3)
11. Duhan van der Merwe (22)
10. Simon Hickey (4)
9. Henry Pyrgos (4)
1. Rory Sutherland (64)
2. Stuart McInally (124) CAPTAIN
3. WP Nel (119)
4. Ben Toolis (93)
5. Grant Gilchrist (124)
6. Magnus Bradbury (56)
7. Hamish Watson (85)
8. Bill Mata (40)
Replacements: 16. Ross Ford (182); 17. Murray McCallum (42); 18. Simon Berghan (52); 19. Luke Hamilton (4); 20. Jamie Ritchie (53); 21. Sean Kennedy (63); 22. Jaco van der Walt (20); 23. Chris Dean (68).