Ireland have made 11 changes to side that narrowly lost to World Champions South Africa at the weekend for their game against Samoa.
Leinster’s Devin Toner will win his first senior cap as he packs down in the second row alongside the experienced Donncha O’Callaghan.
Ireland have selected an all new front row with Tom Court, Sean Cronin and John Hayes selected to start.
Denis Leamy and Sean O'Brien are called into the back row to play alongside Jamie Heaslip who retains the number 8 jersey.
Luke Fitzgerald makes the switch from wing to full-back, with Andrew Trimble coming into the vacant left wing position.
Paddy Wallace also comes into the team at inside centre to partner captain Brian O'Driscoll, and Ronan O'Gara and Peter Stringer, both used as replacements against South Africa, will form the starting half-back combination.
"I'm delighted to be selected…over the moon. I'm just excited now and can't wait for the game,” said Toner
"I found out yesterday when the team was announced. I wasn't told beforehand, so I got a bit of a shock.
"I've been involved in Irish squads before. You're always kind of hoping to get selected. When I saw the four games for this series, I was hopeful (of getting a first cap).
"I'm very pleased to get the call and just looking forward to playing now."
The replacements bench will be finalised after training on Thursday.
Luke Fitzgerald (Blackrock College/Leinster), Tommy Bowe (Ospreys), Brian O'Driscoll (UCD/Leinster) (capt), Paddy Wallace (Ballymena/Ulster), Andrew Trimble (Ballymena/Ulster), Ronan O'Gara (Cork Constitution/Munster), Peter Stringer (Shannon/Munster), Tom Court (Malone/Ulster), Sean Cronin (Buccaneers/Connacht), John Hayes (Bruff/Munster), Donncha O'Callaghan (Cork Constitution/Munster), Devin Toner (Lansdowne/Leinster), Denis Leamy (Cork Constitution/Munster), Sean O'Brien (St. Mary's College/Leinster), Jamie Heaslip (Naas/Leinster).